相互作用
Flutamide + Valoctocogene roxaparvovec
重症度: 重大
Flutamide and Valoctocogene roxaparvovec: major interaction.
最終更新日
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概要
Flutamide carries a boxed warning for hepatotoxicity, and valoctocogene roxaparvovec commonly causes transaminase elevations. Combining them may raise the risk of liver injury and complicate interpretation of liver tests.
この相互作用をわかりやすく説明すると
Flutamide and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Valoctocogene roxaparvovec belongs to Miscellaneous.
なぜ起こるのか
Additive hepatotoxicity from two agents that each can injure the liver.
対処法
Avoid flutamide where possible around gene therapy; if unavoidable, monitor ALT/AST frequently and use an alternative antiandrogen with less hepatotoxic potential.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FlutamideとValoctocogene roxaparvovecの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Flutamideのその他の相互作用
Valoctocogene roxaparvovecのその他の相互作用
よくある質問
Can I take Flutamide with Valoctocogene roxaparvovec?
MediHelp rates the interaction as major. Flutamide and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flutamide carries a boxed warning for hepatotoxicity, and valoctocogene roxaparvovec commonly causes transaminase elevations. Combining them may raise the risk of liver injury and complicate interpretation of liver tests.
How serious is the interaction between Flutamide and Valoctocogene roxaparvovec?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid flutamide where possible around gene therapy; if unavoidable, monitor ALT/AST frequently and use an alternative antiandrogen with less hepatotoxic potential.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
