相互作用
Valoctocogene roxaparvovec + Valproic acid
重症度: 重大
Valoctocogene roxaparvovec and Valproic acid: major interaction.
最終更新日
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概要
Valoctocogene roxaparvovec commonly causes transaminase elevations, and valproate is also hepatotoxic. Concurrent use may increase liver injury and may reduce the response to gene therapy.
この相互作用をわかりやすく説明すると
Valoctocogene roxaparvovec and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Valoctocogene roxaparvovec belongs to Miscellaneous; Valproic acid belongs to Central Nervous System.
なぜ起こるのか
Additive hepatotoxicity from two hepatotoxic agents.
対処法
Monitor liver enzymes frequently after infusion and consider an alternative anticonvulsant if feasible. Manage any transaminase rise according to the gene therapy protocol.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Valoctocogene roxaparvovecとValproic acidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Valproic acidのその他の相互作用
Valoctocogene roxaparvovecのその他の相互作用
よくある質問
Can I take Valoctocogene roxaparvovec with Valproic acid?
MediHelp rates the interaction as major. Valoctocogene roxaparvovec and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valoctocogene roxaparvovec commonly causes transaminase elevations, and valproate is also hepatotoxic. Concurrent use may increase liver injury and may reduce the response to gene therapy.
How serious is the interaction between Valoctocogene roxaparvovec and Valproic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes frequently after infusion and consider an alternative anticonvulsant if feasible. Manage any transaminase rise according to the gene therapy protocol.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
