相互作用
Alogliptin-pioglitazone + Cannabidiol
重症度: 中等度
Alogliptin-pioglitazone and Cannabidiol: moderate interaction.
最終更新日
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概要
Cannabidiol may inhibit CYP2C8, the main enzyme clearing pioglitazone, and could raise pioglitazone levels. This may increase the risk of fluid retention, edema, weight gain and hypoglycemia.
この相互作用をわかりやすく説明すると
Alogliptin-pioglitazone and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-pioglitazone belongs to Endocrine; Cannabidiol belongs to Central Nervous System.
なぜ起こるのか
Inhibition of CYP2C8-mediated pioglitazone metabolism.
対処法
Monitor for edema, weight gain and glycemic changes when cannabidiol is started, and reduce the pioglitazone dose if adverse effects appear.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Alogliptin-pioglitazoneとCannabidiolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Alogliptin-pioglitazoneのその他の相互作用
Cannabidiolのその他の相互作用
よくある質問
Can I take Alogliptin-pioglitazone with Cannabidiol?
MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol may inhibit CYP2C8, the main enzyme clearing pioglitazone, and could raise pioglitazone levels. This may increase the risk of fluid retention, edema, weight gain and hypoglycemia.
How serious is the interaction between Alogliptin-pioglitazone and Cannabidiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for edema, weight gain and glycemic changes when cannabidiol is started, and reduce the pioglitazone dose if adverse effects appear.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
