相互作用
Cannabidiol + Sodium valproate
重症度: 重大
Cannabidiol and Sodium valproate: major interaction.
最終更新日
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概要
Concurrent use increases the incidence of raised liver transaminases compared with either drug alone. Cases of significant hepatotoxicity may occur.
この相互作用をわかりやすく説明すると
Cannabidiol and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cannabidiol belongs to Central Nervous System; Sodium valproate belongs to Central Nervous System.
なぜ起こるのか
Probably additive hepatotoxicity; the exact mechanism is not established.
対処法
Check liver enzymes and bilirubin before treatment and periodically thereafter. Reduce or stop one or both drugs if transaminases rise significantly.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CannabidiolとSodium valproateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cannabidiolのその他の相互作用
Sodium valproateのその他の相互作用
よくある質問
Can I take Cannabidiol with Sodium valproate?
MediHelp rates the interaction as major. Cannabidiol and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use increases the incidence of raised liver transaminases compared with either drug alone. Cases of significant hepatotoxicity may occur.
How serious is the interaction between Cannabidiol and Sodium valproate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes and bilirubin before treatment and periodically thereafter. Reduce or stop one or both drugs if transaminases rise significantly.
What other medicines interact with Cannabidiol?
MediHelp also lists interactions of Cannabidiol with, for example, Phenytoin, Tacrolimus, Abiraterone. The full list is on the Cannabidiol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
