相互作用
Amikacin + Zoledronic acid
重症度: 中等度
Amikacin and Zoledronic acid: moderate interaction.
最終更新日
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概要
Both zoledronic acid and aminoglycosides can lower serum calcium and magnesium, and both are nephrotoxic. Combined use may cause additive hypocalcemia and renal impairment.
この相互作用をわかりやすく説明すると
Amikacin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Zoledronic acid belongs to Musculoskeletal.
なぜ起こるのか
Additive hypocalcemia and hypomagnesemia, with overlapping nephrotoxicity from renal tubular injury.
対処法
Monitor serum calcium, magnesium and creatinine, and replace electrolytes as needed; keep aminoglycoside exposure short and monitor drug levels.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmikacinとZoledronic acidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Zoledronic acidのその他の相互作用
Amikacinのその他の相互作用
よくある質問
Can I take Amikacin with Zoledronic acid?
MediHelp rates the interaction as moderate. Amikacin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both zoledronic acid and aminoglycosides can lower serum calcium and magnesium, and both are nephrotoxic. Combined use may cause additive hypocalcemia and renal impairment.
How serious is the interaction between Amikacin and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, magnesium and creatinine, and replace electrolytes as needed; keep aminoglycoside exposure short and monitor drug levels.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Bumetanide, Dichlorphenamide, Ethacrynic acid. The full list is on the Zoledronic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
