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Zoledronic acid

Zoledronic acid is a medicine in the class musculoskeletal. It is used for glucocorticoid-induced osteoporosis.

最終更新日

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Musculoskeletal
ATCコード
M05BA08
一般的な剤形
注射剤, 点滴静注剤
一般的な規格
4 mg/5 ml, 5 mg/100 ml, 4 mg
既知の相互作用
19 (中等度: 13 · 軽度: 6)
商品名
37
国・市場
5

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

作用のしくみ

Bisphosphonate; inhibits bone resorption via actions on osteoclast activity, leading to indirect increase in bone density

成人の通常用量（添付文書の要約）

Hypercalcemia of Malignancy (Zometa): No more than 4 mg IV (infused over >15 minutes) once; may be repeated in 7 days

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Unsafe No human data. In rats it caused malformations and fetal loss at about 2 times human exposure. It is stored in bone for years, so a later pregnancy may also be exposed. EU label: contraindicated in pregnancy and not recommended in women who could conceive; US: stop when pregnancy is recognised.
授乳
Unknown No data on passage into milk; infant absorption is unlikely (LactMed). EU (Aclasta): contraindicated while breastfeeding; US oncology labels: do not breastfeed during and after treatment (bone retention); Reclast: weigh benefits. LactMed: prefer an alternative, especially with a newborn.

報告されている副作用

  • Fatigue
  • Vomiting
  • Nausea
  • Constipation
  • Anemia
  • Bone pain

禁忌

  • Pregnancy
  • All indications: Hypersensitivity, including rare cases of urticaria, angioedema, and anaphylactic reaction or shock
  • Nononcologic uses: Hypocalcemia, severe renal impairment (CrCl <35 mL/min or evidence of acute renal impairment)

注意が必要な方

  • Infuse over ≥15 minutes; faster infusion increases renal toxicity
  • Increased risk of osteonecrosis of jaw (advise patients against dental work); reported predominantly in cancer patients treated with IV bisphosphonates
  • Risk of osteonecrosis of the jaw may increase with duration of exposure to bisphosphonates

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (19)

All 19 interactions, with severity and what to do

Pro+会員向け

ページ全体を見る

アカウントを作成してPro+トライアルを始めると、Zoledronic acidの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
  • IV preparation and dilution
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WebでPro+を14日間無料でお試し。カード登録不要。

同じ分類のほかの薬剤

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よくある質問

What is Zoledronic acid used for?

Zoledronic acid is a medicine in the class musculoskeletal. It is used for Glucocorticoid-induced osteoporosis, Hypercalcemia of malignancy, Osteoporosis, Paget's disease.

What side effects have been reported with Zoledronic acid?

Fatigue, Vomiting, Nausea, Constipation, Anemia, Bone pain.

Can Zoledronic acid be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. No human data. In rats it caused malformations and fetal loss at about 2 times human exposure. It is stored in bone for years, so a later pregnancy may also be exposed. EU label: contraindicated in pregnancy and not recommended in women who could conceive; US: stop when pregnancy is recognised. Breastfeeding: Unknown. No data on passage into milk; infant absorption is unlikely (LactMed). EU (Aclasta): contraindicated while breastfeeding; US oncology labels: do not breastfeed during and after treatment (bone retention); Reclast: weigh benefits. LactMed: prefer an alternative, especially with a newborn.

What does Zoledronic acid interact with?

MediHelp lists 19 known interactions for Zoledronic acid. Moderate: 13 · Minor: 6. The most serious include Amikacin, Bumetanide, Dichlorphenamide.

完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで

MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。

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