Drug interactions
Amikacin + Zoledronic acid
Severity: Moderate
Amikacin and Zoledronic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both zoledronic acid and aminoglycosides can lower serum calcium and magnesium, and both are nephrotoxic. Combined use may cause additive hypocalcemia and renal impairment.
What this interaction means in plain words
Amikacin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Zoledronic acid belongs to Musculoskeletal.
Why it happens
Additive hypocalcemia and hypomagnesemia, with overlapping nephrotoxicity from renal tubular injury.
What to do
Monitor serum calcium, magnesium and creatinine, and replace electrolytes as needed; keep aminoglycoside exposure short and monitor drug levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zoledronic acid
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
- Human parathyroid hormone recombinant + Zoledronic acid Moderate
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Zoledronic acid?
MediHelp rates the interaction as moderate. Amikacin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both zoledronic acid and aminoglycosides can lower serum calcium and magnesium, and both are nephrotoxic. Combined use may cause additive hypocalcemia and renal impairment.
How serious is the interaction between Amikacin and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, magnesium and creatinine, and replace electrolytes as needed; keep aminoglycoside exposure short and monitor drug levels.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Bumetanide, Dichlorphenamide, Ethacrynic acid. The full list is on the Zoledronic acid page.
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