相互作用
Aminolevulinic acid + Tretinoin
重症度: 中等度
Aminolevulinic acid and Tretinoin: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Oral aminolevulinic acid causes protoporphyrin IX accumulation and photosensitivity. Tretinoin can increase skin sensitivity to light, so phototoxic reactions such as severe sunburn may be worse. Systemic tretinoin is the main concern; topical use adds little.
この相互作用をわかりやすく説明すると
Aminolevulinic acid and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aminolevulinic acid belongs to Miscellaneous; Tretinoin belongs to Dermatology.
なぜ起こるのか
Additive photosensitizing effects from two agents that increase the skin's reactivity to light.
対処法
Counsel strict photoprotection and avoid sun and bright light exposure after aminolevulinic acid for the period specified in labeling. Avoid giving other photosensitizers perioperatively around dosing.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Aminolevulinic acidとTretinoinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Tretinoinのその他の相互作用
Aminolevulinic acidのその他の相互作用
よくある質問
Can I take Aminolevulinic acid with Tretinoin?
MediHelp rates the interaction as moderate. Aminolevulinic acid and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral aminolevulinic acid causes protoporphyrin IX accumulation and photosensitivity. Tretinoin can increase skin sensitivity to light, so phototoxic reactions such as severe sunburn may be worse. Systemic tretinoin is the main concern; topical use adds little.
How serious is the interaction between Aminolevulinic acid and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict photoprotection and avoid sun and bright light exposure after aminolevulinic acid for the period specified in labeling. Avoid giving other photosensitizers perioperatively around dosing.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
