医薬品リファレンス
Tretinoin
Tretinoin is a medicine in the class dermatology. It is used for acne.
- 薬効分類: Dermatology
- 効能・効果: acne
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Dermatology
- 一般的な剤形
- クリーム剤, ゲル剤, カプセル剤, 溶液, ローション剤
- 一般的な規格
- 0.05%, 0.025%, 10 mg
- 既知の相互作用
- 65 (重大: 7 · 中等度: 20 · 軽度: 38)
- 商品名
- 28
- 国・市場
- 4
何に使われるか
作用のしくみ
Retinoid, induces differentiation and decreased proliferation of APL cells; produces an initial maturation of promyelocytes, followed by a repopulation of the bone marrow and peripheral blood by normal polyclonal hematopoietic cells in patients achieving complete remission
成人の通常用量（添付文書の要約）
Acute Promyelocytic Leukemia: 45 mg/m²/day PO divided q12hr, Discontinue 30 days after complete remission or 90 days after start of treatment (whichever comes first)
妊娠と授乳
- 妊娠
- Unsafe Oral capsules (for leukaemia): retinoid that causes severe birth defects and miscarriage; pregnancy test before, and two contraception methods during and for 1 month after. Creams/gels: little is absorbed, but retinoid labels in the EU/UK advise against use in pregnancy; stop if pregnant.
- 授乳
- Unsafe Oral capsules: not studied; do not breastfeed during treatment and for 1 week after the last dose. Creams and gels: poorly absorbed, so LactMed considers them low risk; do not apply to the nipple or areola and keep the baby's skin off treated areas.
報告されている副作用
- Headache
- Pruritus
- Bone pain
- Erythema
- Fever
- Excessive dryness
注意が必要な方
- Systemic: Leukocytosis may occur
- Systemic: Do not coadminister with other retinoids or in combination with vitamin A because symptoms of hypervitaminosis A
- Systemic: There is risk of thrombosis (both venous and arterial) which may involve any organ system, during first month of treatment
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (65)
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
- Tranexamic acid + Tretinoin Major
- Aminolevulinic acid + Tretinoin Moderate
- Chlorpromazine + Tretinoin Moderate
- Ciprofloxacin + Tretinoin Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Tretinoinの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Tretinoin used for?
Tretinoin is a medicine in the class dermatology. It is used for Acne, Leukemia, Melasma, Wrinkles.
What side effects have been reported with Tretinoin?
Headache, Pruritus, Bone pain, Erythema, Fever, Excessive dryness.
Can Tretinoin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Oral capsules (for leukaemia): retinoid that causes severe birth defects and miscarriage; pregnancy test before, and two contraception methods during and for 1 month after. Creams/gels: little is absorbed, but retinoid labels in the EU/UK advise against use in pregnancy; stop if pregnant. Breastfeeding: Unsafe. Oral capsules: not studied; do not breastfeed during treatment and for 1 week after the last dose. Creams and gels: poorly absorbed, so LactMed considers them low risk; do not apply to the nipple or areola and keep the baby's skin off treated areas.
What does Tretinoin interact with?
MediHelp lists 65 known interactions for Tretinoin. Major: 7 · Moderate: 20 · Minor: 38. The most serious include Doxycycline, Minocycline, Omadacycline.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
