相互作用
Amisulpride + Droperidol
重症度: 併用禁忌
Amisulpride and Droperidol: contraindicated interaction.
最終更新日
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概要
Both drugs are dopamine antagonists that prolong the QT interval, so combining them raises the risk of torsades de pointes. Additive dopamine blockade also increases extrapyramidal effects and neuroleptic malignant syndrome risk.
この相互作用をわかりやすく説明すると
Amisulpride and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive QT prolongation and dopamine D2 receptor blockade.
対処法
Avoid the combination; use an antiemetic without QT effects. If unavoidable, monitor ECG and electrolytes.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとDroperidolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amisulprideのその他の相互作用
よくある質問
Can I take Amisulpride with Droperidol?
MediHelp rates the interaction as contraindicated. Amisulpride and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are dopamine antagonists that prolong the QT interval, so combining them raises the risk of torsades de pointes. Additive dopamine blockade also increases extrapyramidal effects and neuroleptic malignant syndrome risk.
How serious is the interaction between Amisulpride and Droperidol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an antiemetic without QT effects. If unavoidable, monitor ECG and electrolytes.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
