相互作用
Amiodarone + Atomoxetine
重症度: 重大
Amiodarone and Atomoxetine: major interaction.
最終更新日
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概要
Amiodarone prolongs the QT interval and atomoxetine may add to this effect, and it can also increase heart rate and blood pressure. Amiodarone's CYP2D6 inhibition may further increase atomoxetine exposure.
この相互作用をわかりやすく説明すると
Amiodarone and Atomoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Atomoxetine belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation, with amiodarone inhibition of CYP2D6 raising atomoxetine levels.
対処法
Avoid if feasible. If combined, monitor ECG, heart rate and blood pressure, and consider a lower atomoxetine dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとAtomoxetineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Atomoxetineのその他の相互作用
よくある質問
Can I take Amiodarone with Atomoxetine?
MediHelp rates the interaction as major. Amiodarone and Atomoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone prolongs the QT interval and atomoxetine may add to this effect, and it can also increase heart rate and blood pressure. Amiodarone's CYP2D6 inhibition may further increase atomoxetine exposure.
How serious is the interaction between Amiodarone and Atomoxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if feasible. If combined, monitor ECG, heart rate and blood pressure, and consider a lower atomoxetine dose.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
