Drug interactions
Amiodarone + Danicopan
Severity: Moderate
Amiodarone and Danicopan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and may increase exposure to amiodarone, a P-gp substrate. Higher amiodarone levels could increase bradycardia, QT prolongation and other toxicity.
What this interaction means in plain words
Amiodarone and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Danicopan belongs to Miscellaneous.
Why it happens
Danicopan inhibits intestinal P-gp efflux, increasing amiodarone absorption.
What to do
Monitor ECG and heart rate, and consider reducing the amiodarone dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Danicopan
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
- Colchicine + Danicopan Moderate
Frequently asked questions
Can I take Amiodarone with Danicopan?
MediHelp rates the interaction as moderate. Amiodarone and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and may increase exposure to amiodarone, a P-gp substrate. Higher amiodarone levels could increase bradycardia, QT prolongation and other toxicity.
How serious is the interaction between Amiodarone and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, and consider reducing the amiodarone dose if toxicity appears.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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