相互作用
Amiodarone + Granisetron
重症度: 重大
Amiodarone and Granisetron: major interaction.
最終更新日
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概要
Amiodarone markedly prolongs the QT interval and granisetron has a smaller QT effect. Together they can add to the risk of torsades de pointes.
この相互作用をわかりやすく説明すると
Amiodarone and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Granisetron belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive QT prolongation through blockade of cardiac repolarizing currents.
対処法
Use a non-QT-prolonging antiemetic if possible. If used together, correct potassium and magnesium and monitor the ECG.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとGranisetronの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Granisetronのその他の相互作用
Amiodaroneのその他の相互作用
よくある質問
Can I take Amiodarone with Granisetron?
MediHelp rates the interaction as major. Amiodarone and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone markedly prolongs the QT interval and granisetron has a smaller QT effect. Together they can add to the risk of torsades de pointes.
How serious is the interaction between Amiodarone and Granisetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antiemetic if possible. If used together, correct potassium and magnesium and monitor the ECG.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amisulpride, Arsenic trioxide. The full list is on the Granisetron page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
