相互作用
Amiodarone + Lemborexant
重症度: 重大
Amiodarone and Lemborexant: major interaction.
最終更新日
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概要
Amiodarone can raise lemborexant exposure through CYP3A4 inhibition. Higher levels may cause excessive sedation, next-day somnolence and impaired psychomotor performance.
この相互作用をわかりやすく説明すると
Amiodarone and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
なぜ起こるのか
Amiodarone inhibits CYP3A4, reducing the metabolic clearance of lemborexant.
対処法
Avoid the combination where possible; if used, keep lemborexant at the lowest recommended dose per labeling for CYP3A inhibitors and monitor for daytime sedation. Consider an alternative hypnotic not dependent on CYP3A4.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとLemborexantの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Lemborexantのその他の相互作用
よくある質問
Can I take Amiodarone with Lemborexant?
MediHelp rates the interaction as major. Amiodarone and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone can raise lemborexant exposure through CYP3A4 inhibition. Higher levels may cause excessive sedation, next-day somnolence and impaired psychomotor performance.
How serious is the interaction between Amiodarone and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, keep lemborexant at the lowest recommended dose per labeling for CYP3A inhibitors and monitor for daytime sedation. Consider an alternative hypnotic not dependent on CYP3A4.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
