相互作用
Amiodarone + Nilotinib
重症度: 併用禁忌
Amiodarone and Nilotinib: contraindicated interaction.
最終更新日
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概要
Nilotinib carries a boxed warning for QT prolongation and sudden death, and amiodarone also prolongs QT. Amiodarone is a CYP3A4 substrate, and nilotinib inhibits CYP3A4, which may raise amiodarone levels and further increase risk.
この相互作用をわかりやすく説明すると
Amiodarone and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Nilotinib belongs to Oncology.
なぜ起こるのか
Additive QT prolongation plus CYP3A4 inhibition by nilotinib increasing amiodarone exposure.
対処法
Do not combine; use an alternative antiarrhythmic or kinase inhibitor. If no alternative exists, require specialist oversight with frequent ECGs and electrolyte correction.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとNilotinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Nilotinibのその他の相互作用
よくある質問
Can I take Amiodarone with Nilotinib?
MediHelp rates the interaction as contraindicated. Amiodarone and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nilotinib carries a boxed warning for QT prolongation and sudden death, and amiodarone also prolongs QT. Amiodarone is a CYP3A4 substrate, and nilotinib inhibits CYP3A4, which may raise amiodarone levels and further increase risk.
How serious is the interaction between Amiodarone and Nilotinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antiarrhythmic or kinase inhibitor. If no alternative exists, require specialist oversight with frequent ECGs and electrolyte correction.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
