相互作用
Ibutilide + Nilotinib
重症度: 併用禁忌
Ibutilide and Nilotinib: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Ibutilide strongly prolongs repolarization and has a high torsades risk. Adding nilotinib, which also prolongs QT, further increases the likelihood of life-threatening ventricular arrhythmia.
この相互作用をわかりやすく説明すると
Ibutilide and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Nilotinib belongs to Oncology.
なぜ起こるのか
Additive QT prolongation via potassium channel blockade.
対処法
Do not use together. Consider another rhythm-control approach such as electrical cardioversion.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IbutilideとNilotinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Nilotinibのその他の相互作用
Ibutilideのその他の相互作用
よくある質問
Can I take Ibutilide with Nilotinib?
MediHelp rates the interaction as contraindicated. Ibutilide and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide strongly prolongs repolarization and has a high torsades risk. Adding nilotinib, which also prolongs QT, further increases the likelihood of life-threatening ventricular arrhythmia.
How serious is the interaction between Ibutilide and Nilotinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Consider another rhythm-control approach such as electrical cardioversion.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
