相互作用
Amiodarone + Propranolol
重症度: 重大
Amiodarone and Propranolol: major interaction.
最終更新日
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概要
Together these drugs can cause additive bradycardia, sinus arrest and AV block, and amiodarone may also raise propranolol levels. Patients with sinus node dysfunction or conduction disease are at highest risk.
この相互作用をわかりやすく説明すると
Amiodarone and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
なぜ起こるのか
Additive negative chronotropic and dromotropic effects, plus amiodarone inhibition of CYP2D6-mediated propranolol metabolism.
対処法
Monitor ECG and heart rate closely, especially at initiation, and reduce the propranolol dose as needed. Avoid in patients with sick sinus syndrome or AV block unless a pacemaker is in place.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとPropranololの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Propranololのその他の相互作用
Amiodaroneのその他の相互作用
よくある質問
Can I take Amiodarone with Propranolol?
MediHelp rates the interaction as major. Amiodarone and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Together these drugs can cause additive bradycardia, sinus arrest and AV block, and amiodarone may also raise propranolol levels. Patients with sinus node dysfunction or conduction disease are at highest risk.
How serious is the interaction between Amiodarone and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate closely, especially at initiation, and reduce the propranolol dose as needed. Avoid in patients with sick sinus syndrome or AV block unless a pacemaker is in place.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
