相互作用
Propranolol + Thioridazine
重症度: 併用禁忌
Propranolol and Thioridazine: contraindicated interaction.
最終更新日
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概要
Thioridazine can raise propranolol concentrations, and propranolol can raise thioridazine concentrations. Because thioridazine itself prolongs the QT interval, higher levels increase the risk of torsades de pointes and sudden death.
この相互作用をわかりやすく説明すると
Propranolol and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Propranolol belongs to Cardiovascular; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Mutual metabolic inhibition involving CYP2D6, with additive cardiac depressant and proarrhythmic effects.
対処法
Avoid concurrent use. If a beta blocker is needed with thioridazine, select one not dependent on CYP2D6 such as atenolol, though thioridazine alternatives are preferred.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、PropranololとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Propranololのその他の相互作用
Thioridazineのその他の相互作用
よくある質問
Can I take Propranolol with Thioridazine?
MediHelp rates the interaction as contraindicated. Propranolol and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine can raise propranolol concentrations, and propranolol can raise thioridazine concentrations. Because thioridazine itself prolongs the QT interval, higher levels increase the risk of torsades de pointes and sudden death.
How serious is the interaction between Propranolol and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If a beta blocker is needed with thioridazine, select one not dependent on CYP2D6 such as atenolol, though thioridazine alternatives are preferred.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Propranolol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
