Drug interactions
Amisulpride + Droperidol
Severity: Contraindicated
Amisulpride and Droperidol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are dopamine antagonists that prolong the QT interval, so combining them raises the risk of torsades de pointes. Additive dopamine blockade also increases extrapyramidal effects and neuroleptic malignant syndrome risk.
What this interaction means in plain words
Amisulpride and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QT prolongation and dopamine D2 receptor blockade.
What to do
Avoid the combination; use an antiemetic without QT effects. If unavoidable, monitor ECG and electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Amisulpride + Pimozide Contraindicated
Frequently asked questions
Can I take Amisulpride with Droperidol?
MediHelp rates the interaction as contraindicated. Amisulpride and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are dopamine antagonists that prolong the QT interval, so combining them raises the risk of torsades de pointes. Additive dopamine blockade also increases extrapyramidal effects and neuroleptic malignant syndrome risk.
How serious is the interaction between Amisulpride and Droperidol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an antiemetic without QT effects. If unavoidable, monitor ECG and electrolytes.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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