相互作用
Amisulpride + Lofexidine
重症度: 重大
Amisulpride and Lofexidine: major interaction.
最終更新日
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概要
Both drugs can prolong the QT interval, and lofexidine also causes bradycardia, which adds to proarrhythmic risk. Together they increase the chance of torsades de pointes.
この相互作用をわかりやすく説明すると
Amisulpride and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation, aggravated by lofexidine-induced bradycardia.
対処法
Avoid if possible. If co-administered, obtain ECG monitoring, correct potassium and magnesium, and monitor heart rate.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとLofexidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lofexidineのその他の相互作用
Amisulprideのその他の相互作用
よくある質問
Can I take Amisulpride with Lofexidine?
MediHelp rates the interaction as major. Amisulpride and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and lofexidine also causes bradycardia, which adds to proarrhythmic risk. Together they increase the chance of torsades de pointes.
How serious is the interaction between Amisulpride and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If co-administered, obtain ECG monitoring, correct potassium and magnesium, and monitor heart rate.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
