相互作用
Amitriptyline + Budesonide-formoterol
重症度: 重大
Amitriptyline and Budesonide-formoterol: major interaction.
最終更新日
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概要
Formoterol can prolong the QT interval and raise heart rate, and amitriptyline has its own QT-prolonging and proarrhythmic effects. Tricyclics can also potentiate the cardiovascular effects of beta-agonists, so the combination may raise the risk of tachyarrhythmia and palpitations.
この相互作用をわかりやすく説明すると
Amitriptyline and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Budesonide-formoterol belongs to Respiratory.
なぜ起こるのか
Additive QT prolongation and adrenergic cardiovascular stimulation, with tricyclic potentiation of sympathomimetic effects.
対処法
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and heart rate, and consider alternatives in patients with cardiac disease or other QT risk factors.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmitriptylineとBudesonide-formoterolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Budesonide-formoterolのその他の相互作用
Amitriptylineのその他の相互作用
よくある質問
Can I take Amitriptyline with Budesonide-formoterol?
MediHelp rates the interaction as major. Amitriptyline and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Formoterol can prolong the QT interval and raise heart rate, and amitriptyline has its own QT-prolonging and proarrhythmic effects. Tricyclics can also potentiate the cardiovascular effects of beta-agonists, so the combination may raise the risk of tachyarrhythmia and palpitations.
How serious is the interaction between Amitriptyline and Budesonide-formoterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and heart rate, and consider alternatives in patients with cardiac disease or other QT risk factors.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
