相互作用
Amisulpride + Budesonide-formoterol
重症度: 重大
Amisulpride and Budesonide-formoterol: major interaction.
最終更新日
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概要
Amisulpride causes dose-related QT prolongation, and formoterol can add tachycardia, hypokalemia and QT effects. Together they raise the risk of torsades de pointes in susceptible patients.
この相互作用をわかりやすく説明すると
Amisulpride and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Budesonide-formoterol belongs to Respiratory.
なぜ起こるのか
Additive effects on cardiac repolarization, with beta-agonist-induced hypokalemia.
対処法
Obtain a baseline ECG and monitor it during co-therapy, and correct potassium and magnesium. Consider an alternative if other QT risk factors are present.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとBudesonide-formoterolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Budesonide-formoterolのその他の相互作用
Amisulprideのその他の相互作用
よくある質問
Can I take Amisulpride with Budesonide-formoterol?
MediHelp rates the interaction as major. Amisulpride and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride causes dose-related QT prolongation, and formoterol can add tachycardia, hypokalemia and QT effects. Together they raise the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Amisulpride and Budesonide-formoterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during co-therapy, and correct potassium and magnesium. Consider an alternative if other QT risk factors are present.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amitriptyline. The full list is on the Budesonide-formoterol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
