相互作用
Amlodipine-hydrochlorothiazide-valsartan + Calcium carbonate
重症度: 中等度
Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate: moderate interaction.
最終更新日
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概要
Thiazides reduce urinary calcium excretion, and with calcium carbonate this can cause hypercalcemia and milk-alkali syndrome, especially with high doses or renal impairment. High-dose calcium may also reduce calcium channel blocker effects, although this is rarely clinically significant at usual intakes.
この相互作用をわかりやすく説明すると
Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Calcium carbonate belongs to Gastrointestinal Tract.
なぜ起こるのか
Thiazide-reduced renal calcium excretion plus calcium load leading to hypercalcemia.
対処法
Monitor serum calcium and renal function, particularly with high calcium doses or long-term use. Reduce calcium supplementation if hypercalcemia develops.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Amlodipine-hydrochlorothiazide-valsartanとCalcium carbonateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-hydrochlorothiazide-valsartanのその他の相互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 併用禁忌
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide 併用禁忌
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan 併用禁忌
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 重大
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 重大
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 重大
Calcium carbonateのその他の相互作用
よくある質問
Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcium carbonate?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, and with calcium carbonate this can cause hypercalcemia and milk-alkali syndrome, especially with high doses or renal impairment. High-dose calcium may also reduce calcium channel blocker effects, although this is rarely clinically significant at usual intakes.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function, particularly with high calcium doses or long-term use. Reduce calcium supplementation if hypercalcemia develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
