相互作用
Amlodipine-olmesartan-hydrochlorothiazide + Calcium carbonate
重症度: 中等度
Amlodipine-olmesartan-hydrochlorothiazide and Calcium carbonate: moderate interaction.
最終更新日
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概要
Calcium salts can reduce the effect of calcium channel blockers in cases of high-dose or intravenous calcium, but oral calcium carbonate has little effect on amlodipine. Thiazides reduce urinary calcium excretion, so with large calcium carbonate doses there is a risk of hypercalcemia and milk-alkali syndrome.
この相互作用をわかりやすく説明すると
Amlodipine-olmesartan-hydrochlorothiazide and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Calcium carbonate belongs to Gastrointestinal Tract.
なぜ起こるのか
Thiazide-reduced renal calcium excretion combined with calcium load, with minimal pharmacodynamic antagonism of amlodipine at oral doses.
対処法
Monitor serum calcium in patients taking regular or high-dose calcium supplements or antacids. Reduce calcium dose if hypercalcemia occurs.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-olmesartan-hydrochlorothiazideのその他の相互作用
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide 併用禁忌
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide 併用禁忌
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan 併用禁忌
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide 重大
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide 重大
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide 重大
Calcium carbonateのその他の相互作用
よくある質問
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Calcium carbonate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium salts can reduce the effect of calcium channel blockers in cases of high-dose or intravenous calcium, but oral calcium carbonate has little effect on amlodipine. Thiazides reduce urinary calcium excretion, so with large calcium carbonate doses there is a risk of hypercalcemia and milk-alkali syndrome.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium in patients taking regular or high-dose calcium supplements or antacids. Reduce calcium dose if hypercalcemia occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
