相互作用
Amobarbital + Clorazepate
重症度: 重大
Amobarbital and Clorazepate: major interaction.
最終更新日
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概要
Barbiturates and benzodiazepines both depress the CNS, so combined use can cause profound sedation, respiratory depression and coma. Amobarbital also induces CYP3A4 and may lower exposure to clorazepate's active metabolite, making the net effect less predictable.
この相互作用をわかりやすく説明すると
Amobarbital and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.
なぜ起こるのか
Additive GABAergic CNS and respiratory depression, plus CYP3A4 induction by amobarbital that increases clearance of the benzodiazepine.
対処法
Avoid the combination where possible, or use the lowest doses with close monitoring of sedation and respiratory status. Reassess clorazepate dosing when the barbiturate is started or stopped.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、AmobarbitalとClorazepateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clorazepateのその他の相互作用
Amobarbitalのその他の相互作用
よくある質問
Can I take Amobarbital with Clorazepate?
MediHelp rates the interaction as major. Amobarbital and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines both depress the CNS, so combined use can cause profound sedation, respiratory depression and coma. Amobarbital also induces CYP3A4 and may lower exposure to clorazepate's active metabolite, making the net effect less predictable.
How serious is the interaction between Amobarbital and Clorazepate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest doses with close monitoring of sedation and respiratory status. Reassess clorazepate dosing when the barbiturate is started or stopped.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
