相互作用
Apalutamide + Doravirine
重症度: 併用禁忌
Apalutamide and Doravirine: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Apalutamide is a strong CYP3A inducer and can markedly lower doravirine plasma concentrations. This may lead to loss of virologic suppression and selection of HIV resistance.
この相互作用をわかりやすく説明すると
Apalutamide and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Doravirine belongs to Anti Virals.
なぜ起こるのか
Apalutamide induces CYP3A4, increasing the metabolism of doravirine, which is a CYP3A substrate.
対処法
Do not coadminister; choose an alternative antiandrogen or antiretroviral regimen without dependence on CYP3A exposure. Allow time for enzyme induction to wane after stopping apalutamide before relying on doravirine.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとDoravirineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Apalutamideのその他の相互作用
Doravirineのその他の相互作用
よくある質問
Can I take Apalutamide with Doravirine?
MediHelp rates the interaction as contraindicated. Apalutamide and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide is a strong CYP3A inducer and can markedly lower doravirine plasma concentrations. This may lead to loss of virologic suppression and selection of HIV resistance.
How serious is the interaction between Apalutamide and Doravirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose an alternative antiandrogen or antiretroviral regimen without dependence on CYP3A exposure. Allow time for enzyme induction to wane after stopping apalutamide before relying on doravirine.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Elbasvir / grazoprevir. The full list is on the Apalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
