相互作用
Amobarbital + Warfarin
重症度: 重大
Amobarbital and Warfarin: major interaction.
最終更新日
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概要
Barbiturates induce hepatic enzymes and accelerate warfarin metabolism, lowering INR and reducing anticoagulant protection. The effect develops over weeks and persists after the barbiturate is stopped, with risk of rebound overanticoagulation.
この相互作用をわかりやすく説明すると
Amobarbital and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
なぜ起こるのか
Induction of hepatic CYP enzymes (including CYP2C9 and CYP3A4) increasing warfarin clearance.
対処法
Monitor INR frequently and increase the warfarin dose as required. Reduce the dose and recheck INR when the barbiturate is discontinued.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとWarfarinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Warfarinのその他の相互作用
Amobarbitalのその他の相互作用
よくある質問
Can I take Amobarbital with Warfarin?
MediHelp rates the interaction as major. Amobarbital and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce hepatic enzymes and accelerate warfarin metabolism, lowering INR and reducing anticoagulant protection. The effect develops over weeks and persists after the barbiturate is stopped, with risk of rebound overanticoagulation.
How serious is the interaction between Amobarbital and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR frequently and increase the warfarin dose as required. Reduce the dose and recheck INR when the barbiturate is discontinued.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
