相互作用
Amphotericin b + Fludrocortisone
重症度: 重大
Amphotericin b and Fludrocortisone: major interaction.
最終更新日
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概要
Fludrocortisone has strong mineralocorticoid activity that promotes potassium excretion, and amphotericin B independently causes potassium wasting. The combination can lead to significant and sometimes severe hypokalemia.
この相互作用をわかりやすく説明すると
Amphotericin b and Fludrocortisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Fludrocortisone belongs to Endocrine.
なぜ起こるのか
Additive renal potassium loss from mineralocorticoid receptor stimulation and amphotericin B-induced distal tubular leak.
対処法
Monitor potassium and magnesium frequently and give replacement early. Reassess the need for fludrocortisone dose or concurrent use if hypokalemia persists.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amphotericin bとFludrocortisoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amphotericin bのその他の相互作用
Fludrocortisoneのその他の相互作用
- Fludrocortisone + Mifepristone 併用禁忌
- Aldesleukin + Fludrocortisone 重大
- Bcg vaccine live + Fludrocortisone 重大
- Fludrocortisone + Influenza virus vaccine quadrivalent intranasal 重大
- Fludrocortisone + Measles mumps and rubella vaccine live 重大
- Fludrocortisone + Measles mumps rubella and varicella vaccine live 重大
よくある質問
Can I take Amphotericin b with Fludrocortisone?
MediHelp rates the interaction as major. Amphotericin b and Fludrocortisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fludrocortisone has strong mineralocorticoid activity that promotes potassium excretion, and amphotericin B independently causes potassium wasting. The combination can lead to significant and sometimes severe hypokalemia.
How serious is the interaction between Amphotericin b and Fludrocortisone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium frequently and give replacement early. Reassess the need for fludrocortisone dose or concurrent use if hypokalemia persists.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
