相互作用
Amphotericin b liposomal + Tenofovir disoproxil
重症度: 中等度
Amphotericin b liposomal and Tenofovir disoproxil: moderate interaction.
最終更新日
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概要
Both drugs can injure the kidney, and giving them together may add to the risk of renal impairment. Reduced kidney function can in turn raise tenofovir exposure and worsen tubular toxicity. The liposomal formulation is generally less nephrotoxic than conventional amphotericin B.
この相互作用をわかりやすく説明すると
Amphotericin b liposomal and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Additive nephrotoxicity, with reduced renal clearance of tenofovir when kidney function declines.
対処法
Monitor serum creatinine, estimated creatinine clearance, phosphate and electrolytes regularly during combined use. Adjust the tenofovir interval for renal function or choose an alternative if renal function falls.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amphotericin b liposomalとTenofovir disoproxilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amphotericin b liposomalのその他の相互作用
よくある質問
Can I take Amphotericin b liposomal with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney, and giving them together may add to the risk of renal impairment. Reduced kidney function can in turn raise tenofovir exposure and worsen tubular toxicity. The liposomal formulation is generally less nephrotoxic than conventional amphotericin B.
How serious is the interaction between Amphotericin b liposomal and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, estimated creatinine clearance, phosphate and electrolytes regularly during combined use. Adjust the tenofovir interval for renal function or choose an alternative if renal function falls.
What other medicines interact with Amphotericin b liposomal?
MediHelp also lists interactions of Amphotericin b liposomal with, for example, Amlodipine-benazepril, Benazepril, Captopril-hydrochlorothiazide. The full list is on the Amphotericin b liposomal page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
