相互作用
Ampicillin-sulbactam + Chloramphenicol
重症度: 中等度
Ampicillin-sulbactam and Chloramphenicol: moderate interaction.
最終更新日
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概要
Chloramphenicol is bacteriostatic and may reduce the killing activity of beta-lactams in vitro. Clinical significance is uncertain, but it may matter in severe infections such as meningitis.
この相互作用をわかりやすく説明すると
Ampicillin-sulbactam and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ampicillin-sulbactam belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
なぜ起こるのか
Pharmacodynamic antagonism, as inhibition of bacterial protein synthesis may reduce the cell-wall-dependent bactericidal effect of the beta-lactam.
対処法
Avoid combining them in serious infections where bactericidal activity is essential, and choose a single appropriate agent where possible. If used together, monitor clinical and microbiological response.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Ampicillin-sulbactamとChloramphenicolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ampicillin-sulbactamのその他の相互作用
Chloramphenicolのその他の相互作用
よくある質問
Can I take Ampicillin-sulbactam with Chloramphenicol?
MediHelp rates the interaction as moderate. Ampicillin-sulbactam and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol is bacteriostatic and may reduce the killing activity of beta-lactams in vitro. Clinical significance is uncertain, but it may matter in severe infections such as meningitis.
How serious is the interaction between Ampicillin-sulbactam and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them in serious infections where bactericidal activity is essential, and choose a single appropriate agent where possible. If used together, monitor clinical and microbiological response.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
