相互作用
Arformoterol + Cisapride
重症度: 重大
Arformoterol and Cisapride: major interaction.
最終更新日
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概要
Cisapride prolongs the QT interval, and long-acting beta-agonists such as arformoterol can cause hypokalemia, tachycardia and QT prolongation. The combination increases the risk of ventricular arrhythmias including torsades de pointes.
この相互作用をわかりやすく説明すると
Arformoterol and Cisapride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arformoterol belongs to Respiratory; Cisapride belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive QT prolongation with beta-agonist-related hypokalemia and increased heart rate.
対処法
Avoid the combination if possible and use a non-QT-prolonging prokinetic. If unavoidable, monitor ECG and correct potassium and magnesium.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ArformoterolとCisaprideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Cisaprideのその他の相互作用
Arformoterolのその他の相互作用
よくある質問
Can I take Arformoterol with Cisapride?
MediHelp rates the interaction as major. Arformoterol and Cisapride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisapride prolongs the QT interval, and long-acting beta-agonists such as arformoterol can cause hypokalemia, tachycardia and QT prolongation. The combination increases the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Arformoterol and Cisapride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use a non-QT-prolonging prokinetic. If unavoidable, monitor ECG and correct potassium and magnesium.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
