相互作用
Aripiprazole + Carbamazepine
重症度: 重大
Aripiprazole and Carbamazepine: major interaction.
最終更新日
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概要
Carbamazepine markedly lowers aripiprazole concentrations by enzyme induction, which may cause relapse of psychiatric symptoms.
この相互作用をわかりやすく説明すると
Aripiprazole and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Carbamazepine belongs to Central Nervous System.
なぜ起こるのか
Induction of CYP3A4 by carbamazepine increases aripiprazole clearance.
対処法
Double the aripiprazole dose when carbamazepine is added and monitor response. Reduce it back when carbamazepine is stopped.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AripiprazoleとCarbamazepineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Aripiprazoleのその他の相互作用
Carbamazepineのその他の相互作用
よくある質問
Can I take Aripiprazole with Carbamazepine?
MediHelp rates the interaction as major. Aripiprazole and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine markedly lowers aripiprazole concentrations by enzyme induction, which may cause relapse of psychiatric symptoms.
How serious is the interaction between Aripiprazole and Carbamazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Double the aripiprazole dose when carbamazepine is added and monitor response. Reduce it back when carbamazepine is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
