相互作用
Aripiprazole + Arsenic trioxide
重症度: 重大
Aripiprazole and Arsenic trioxide: major interaction.
最終更新日
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概要
Arsenic trioxide causes marked QT prolongation and torsades de pointes. Aripiprazole has a small QT liability, so the effects may be additive, although aripiprazole is among the lower-risk antipsychotics.
この相互作用をわかりやすく説明すると
Aripiprazole and Arsenic trioxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Arsenic trioxide belongs to Oncology.
なぜ起こるのか
Additive prolongation of cardiac repolarization.
対処法
Avoid other QT-prolonging drugs during arsenic trioxide therapy where alternatives exist. If aripiprazole must continue, monitor ECG and keep potassium and magnesium within normal range.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AripiprazoleとArsenic trioxideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Aripiprazoleのその他の相互作用
Arsenic trioxideのその他の相互作用
よくある質問
Can I take Aripiprazole with Arsenic trioxide?
MediHelp rates the interaction as major. Aripiprazole and Arsenic trioxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide causes marked QT prolongation and torsades de pointes. Aripiprazole has a small QT liability, so the effects may be additive, although aripiprazole is among the lower-risk antipsychotics.
How serious is the interaction between Aripiprazole and Arsenic trioxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid other QT-prolonging drugs during arsenic trioxide therapy where alternatives exist. If aripiprazole must continue, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
