相互作用
Amisulpride + Aripiprazole
重症度: 重大
Amisulpride and Aripiprazole: major interaction.
最終更新日
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概要
Giving aripiprazole together with amisulpride puts two antipsychotics on the same dopaminergic and QT-related pathways. Extrapyramidal reactions, hyperprolactinaemia and QT prolongation are all more probable.
この相互作用をわかりやすく説明すると
Amisulpride and Aripiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Aripiprazole belongs to Central Nervous System.
なぜ起こるのか
Additive dopamine receptor antagonism and QTc prolongation
対処法
Avoid antipsychotic polypharmacy where possible; if used, monitor ECG, EPS and prolactin.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとAripiprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Aripiprazoleのその他の相互作用
Amisulprideのその他の相互作用
よくある質問
Can I take Amisulpride with Aripiprazole?
MediHelp rates the interaction as major. Amisulpride and Aripiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Giving aripiprazole together with amisulpride puts two antipsychotics on the same dopaminergic and QT-related pathways. Extrapyramidal reactions, hyperprolactinaemia and QT prolongation are all more probable.
How serious is the interaction between Amisulpride and Aripiprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible; if used, monitor ECG, EPS and prolactin.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Arsenic trioxide. The full list is on the Aripiprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
