相互作用
Artesunate + Rifampicin
重症度: 重大
Artesunate and Rifampicin: major interaction.
最終更新日
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概要
Rifampicin induces glucuronidation and can lower dihydroartemisinin exposure, reducing antimalarial effect. Failure of malaria treatment can be serious.
この相互作用をわかりやすく説明すると
Artesunate and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Artesunate belongs to Anti Parasitic; Rifampicin belongs to Anti Bacterial.
なぜ起こるのか
Rifampicin induces UGT enzymes, increasing clearance of dihydroartemisinin, the active metabolite.
対処法
Avoid if possible; if unavoidable, monitor parasitemia and clinical response closely and consider alternative therapy.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ArtesunateとRifampicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Artesunateのその他の相互作用
Rifampicinのその他の相互作用
よくある質問
Can I take Artesunate with Rifampicin?
MediHelp rates the interaction as major. Artesunate and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin induces glucuronidation and can lower dihydroartemisinin exposure, reducing antimalarial effect. Failure of malaria treatment can be serious.
How serious is the interaction between Artesunate and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, monitor parasitemia and clinical response closely and consider alternative therapy.
What other medicines interact with Artesunate?
MediHelp also lists interactions of Artesunate with, for example, Carbamazepine, Eltrombopag, Imatinib. The full list is on the Artesunate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
