相互作用
Artesunate + Nevirapine
重症度: 中等度
Artesunate and Nevirapine: moderate interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Nevirapine may reduce exposure to dihydroartemisinin, the active metabolite of artesunate, by inducing metabolic enzymes. This may reduce antimalarial efficacy.
この相互作用をわかりやすく説明すると
Artesunate and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Nevirapine belongs to Anti Virals.
なぜ起こるのか
Nevirapine induces CYP enzymes and UGT-mediated clearance, lowering active artesunate metabolite exposure.
対処法
Use the full recommended artesunate course and monitor parasitological and clinical response. Consider follow-up testing for recrudescence.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ArtesunateとNevirapineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Nevirapineのその他の相互作用
Artesunateのその他の相互作用
よくある質問
Can I take Artesunate with Nevirapine?
MediHelp rates the interaction as moderate. Artesunate and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce exposure to dihydroartemisinin, the active metabolite of artesunate, by inducing metabolic enzymes. This may reduce antimalarial efficacy.
How serious is the interaction between Artesunate and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the full recommended artesunate course and monitor parasitological and clinical response. Consider follow-up testing for recrudescence.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
