相互作用
Asenapine + Macimorelin
重症度: 重大
Asenapine and Macimorelin: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Macimorelin prolongs the QT interval and asenapine has a similar effect, so concurrent use can increase the risk of torsade de pointes. Macimorelin is used as a single-dose diagnostic test, so the exposure is short.
この相互作用をわかりやすく説明すると
Asenapine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Macimorelin belongs to Endocrine.
なぜ起こるのか
Additive prolongation of cardiac repolarization (QT interval).
対処法
Avoid giving macimorelin to patients taking asenapine, and allow adequate washout of QT-prolonging drugs before testing. If the test is essential, consider an alternative diagnostic approach or ECG monitoring.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AsenapineとMacimorelinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Asenapineのその他の相互作用
Macimorelinのその他の相互作用
よくある質問
Can I take Asenapine with Macimorelin?
MediHelp rates the interaction as major. Asenapine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin prolongs the QT interval and asenapine has a similar effect, so concurrent use can increase the risk of torsade de pointes. Macimorelin is used as a single-dose diagnostic test, so the exposure is short.
How serious is the interaction between Asenapine and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking asenapine, and allow adequate washout of QT-prolonging drugs before testing. If the test is essential, consider an alternative diagnostic approach or ECG monitoring.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
