相互作用
Aspirin / citric acid / sodium bicarbonate + Ticlopidine
重症度: 重大
Aspirin / citric acid / sodium bicarbonate and Ticlopidine: major interaction.
最終更新日
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概要
The effervescent aspirin product delivers analgesic or antiplatelet doses of aspirin, which together with ticlopidine increases bleeding risk. The high-dose aspirin typical of these products and its GI irritation make this more hazardous.
この相互作用をわかりやすく説明すると
Aspirin / citric acid / sodium bicarbonate and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive antiplatelet effect through COX-1 inhibition and P2Y12 blockade, plus aspirin-induced mucosal injury.
対処法
Avoid analgesic-dose aspirin products with ticlopidine; if aspirin is needed, use low-dose and monitor for bleeding and blood counts.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Aspirin / citric acid / sodium bicarbonateとTiclopidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ticlopidineのその他の相互作用
よくある質問
Can I take Aspirin / citric acid / sodium bicarbonate with Ticlopidine?
MediHelp rates the interaction as major. Aspirin / citric acid / sodium bicarbonate and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The effervescent aspirin product delivers analgesic or antiplatelet doses of aspirin, which together with ticlopidine increases bleeding risk. The high-dose aspirin typical of these products and its GI irritation make this more hazardous.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid analgesic-dose aspirin products with ticlopidine; if aspirin is needed, use low-dose and monitor for bleeding and blood counts.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
