Drug interactions
Aspirin / citric acid / sodium bicarbonate + Ticlopidine
Severity: Major
Aspirin / citric acid / sodium bicarbonate and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The effervescent aspirin product delivers analgesic or antiplatelet doses of aspirin, which together with ticlopidine increases bleeding risk. The high-dose aspirin typical of these products and its GI irritation make this more hazardous.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antiplatelet effect through COX-1 inhibition and P2Y12 blockade, plus aspirin-induced mucosal injury.
What to do
Avoid analgesic-dose aspirin products with ticlopidine; if aspirin is needed, use low-dose and monitor for bleeding and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticlopidine
- Mavacamten + Ticlopidine Contraindicated
- Abrocitinib + Ticlopidine Major
- Acetylsalicylic acid + Ticlopidine Major
- Apixaban + Ticlopidine Major
- Aspirin rectal + Ticlopidine Major
- Aspirin + Ticlopidine Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Ticlopidine?
MediHelp rates the interaction as major. Aspirin / citric acid / sodium bicarbonate and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The effervescent aspirin product delivers analgesic or antiplatelet doses of aspirin, which together with ticlopidine increases bleeding risk. The high-dose aspirin typical of these products and its GI irritation make this more hazardous.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid analgesic-dose aspirin products with ticlopidine; if aspirin is needed, use low-dose and monitor for bleeding and blood counts.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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