医薬品リファレンス
Ticlopidine
Ticlopidine is a medicine in the class cardiovascular. It is used for coronary artery stent thrombosis.
- 薬効分類: Cardiovascular
- 効能・効果: coronary artery stent thrombosis
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Cardiovascular
- 一般的な剤形
- 錠剤
- 一般的な規格
- 250 mg
- 既知の相互作用
- 113 (併用禁忌: 1 · 重大: 32 · 中等度: 52 · 軽度: 28)
- 商品名
- 3
- 国・市場
- 2
何に使われるか
作用のしくみ
Platelet aggregation inhibitor; reversibly interacts with the platelet P2Y12 ADP-receptor to prevent signal transduction and platelet activation
成人の通常用量（添付文書の要約）
Stroke: 250 mg PO q12hr with food
妊娠と授乳
- 妊娠
- Unknown Largely withdrawn (blood disorders); clopidogrel has replaced it. Animal studies at high doses showed no birth defects; human data are very limited. Avoid in pregnancy; if an antiplatelet is needed, clopidogrel or low-dose aspirin is preferred.
- 授乳
- Unknown Not known if it passes into milk; no LactMed record. The old US label advised stopping the drug or nursing. Because of its serious blood side effects (neutropenia, TTP), avoid while breastfeeding and use an alternative.
報告されている副作用
- Diarrhea
- Nausea
- Rash
- Dyspepsia
- Elevated alkaline phosphatase
警告（枠囲み警告）
- May cause life-threatening hematologic events, including neutropenia, agranulocytosis, thrombocytopenia purpura, and aplastic anemia
禁忌
- Neutropenia, thrombocytopenia, hemostatic disorder or active bleeding (GI bleed, ICH), severe hepatic impairment, history of either thrombotic thrombocytopenic purpura (TTP) or aplastic anemia
- Current use of other anticoagulant drugs
注意が必要な方
- Increases serum chlesterol & triglyceride concentrations
- Patients with lesions that have a propensity to bleed
- Due to risk of adverse hematologic events, for stroke prevention use only in ASA-intolerant patients
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (113)
- Mavacamten + Ticlopidine Contraindicated
- Abrocitinib + Ticlopidine Major
- Acetylsalicylic acid + Ticlopidine Major
- Apixaban + Ticlopidine Major
- Aspirin + Ticlopidine Major
- Aspirin / citric acid / sodium bicarbonate + Ticlopidine Major
- Aspirin rectal + Ticlopidine Major
- Betrixaban + Ticlopidine Major
- Carbamazepine + Ticlopidine Major
- Cilostazol + Ticlopidine Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Ticlopidineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Ticlopidine used for?
Ticlopidine is a medicine in the class cardiovascular. It is used for Coronary artery stent thrombosis, Stroke.
What side effects have been reported with Ticlopidine?
Diarrhea, Nausea, Rash, Dyspepsia, Elevated alkaline phosphatase. Serious warning: May cause life-threatening hematologic events, including neutropenia, agranulocytosis, thrombocytopenia purpura, and aplastic anemia
Can Ticlopidine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Largely withdrawn (blood disorders); clopidogrel has replaced it. Animal studies at high doses showed no birth defects; human data are very limited. Avoid in pregnancy; if an antiplatelet is needed, clopidogrel or low-dose aspirin is preferred. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed record. The old US label advised stopping the drug or nursing. Because of its serious blood side effects (neutropenia, TTP), avoid while breastfeeding and use an alternative.
What does Ticlopidine interact with?
MediHelp lists 113 known interactions for Ticlopidine. Contraindicated: 1 · Major: 32 · Moderate: 52 · Minor: 28. The most serious include Mavacamten, Abrocitinib, Acetylsalicylic acid.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
