相互作用
Mavacamten + Ticlopidine
重症度: 併用禁忌
Mavacamten and Ticlopidine: contraindicated interaction.
最終更新日
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概要
Ticlopidine inhibits CYP2C19, which is the main route of mavacamten metabolism, and may raise its exposure. Excess mavacamten can reduce ejection fraction and lead to heart failure from systolic dysfunction. The labeling contraindicates moderate to strong CYP2C19 inhibitors.
この相互作用をわかりやすく説明すると
Mavacamten and Ticlopidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mavacamten belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
なぜ起こるのか
Inhibition of CYP2C19 by ticlopidine reduces mavacamten clearance.
対処法
Avoid the combination and choose an alternative antiplatelet drug if possible. If it cannot be avoided, monitor LVEF closely and consider mavacamten dose reduction or interruption.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、MavacamtenとTiclopidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ticlopidineのその他の相互作用
Mavacamtenのその他の相互作用
よくある質問
Can I take Mavacamten with Ticlopidine?
MediHelp rates the interaction as contraindicated. Mavacamten and Ticlopidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ticlopidine inhibits CYP2C19, which is the main route of mavacamten metabolism, and may raise its exposure. Excess mavacamten can reduce ejection fraction and lead to heart failure from systolic dysfunction. The labeling contraindicates moderate to strong CYP2C19 inhibitors.
How serious is the interaction between Mavacamten and Ticlopidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiplatelet drug if possible. If it cannot be avoided, monitor LVEF closely and consider mavacamten dose reduction or interruption.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Abrocitinib, Acetylsalicylic acid, Apixaban. The full list is on the Ticlopidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
