相互作用
Atazanavir + Famotidine
重症度: 重大
Atazanavir and Famotidine: major interaction.
最終更新日
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概要
Atazanavir needs an acidic stomach for dissolution, and famotidine raises gastric pH. This can substantially lower atazanavir levels and risk virologic failure and resistance.
この相互作用をわかりやすく説明すると
Atazanavir and Famotidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Famotidine belongs to Gastrointestinal Tract.
なぜ起こるのか
Famotidine raises gastric pH, reducing the pH-dependent solubility and absorption of atazanavir.
対処法
Give atazanavir with or at least 10 hours after the H2 blocker, and use ritonavir boosting at labeled doses; limit the H2 blocker dose to labeled maximums.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとFamotidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Famotidineのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Famotidine?
MediHelp rates the interaction as major. Atazanavir and Famotidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic stomach for dissolution, and famotidine raises gastric pH. This can substantially lower atazanavir levels and risk virologic failure and resistance.
How serious is the interaction between Atazanavir and Famotidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give atazanavir with or at least 10 hours after the H2 blocker, and use ritonavir boosting at labeled doses; limit the H2 blocker dose to labeled maximums.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Dasatinib, Infigratinib, Itraconazole. The full list is on the Famotidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
