相互作用
Atazanavir + Dronedarone
重症度: 併用禁忌
Atazanavir and Dronedarone: contraindicated interaction.
最終更新日
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概要
Atazanavir inhibits CYP3A4, especially when boosted, and can raise dronedarone levels. Atazanavir also prolongs PR and QT intervals, increasing the risk of conduction block and arrhythmia.
この相互作用をわかりやすく説明すると
Atazanavir and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Dronedarone belongs to Cardiovascular.
なぜ起こるのか
CYP3A4 inhibition decreases dronedarone clearance, with additive effects on cardiac conduction.
対処法
Do not co-administer; choose an alternative antiretroviral or antiarrhythmic.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとDronedaroneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dronedaroneのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Dronedarone?
MediHelp rates the interaction as contraindicated. Atazanavir and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir inhibits CYP3A4, especially when boosted, and can raise dronedarone levels. Atazanavir also prolongs PR and QT intervals, increasing the risk of conduction block and arrhythmia.
How serious is the interaction between Atazanavir and Dronedarone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an alternative antiretroviral or antiarrhythmic.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
