相互作用
Atazanavir + Eletriptan
重症度: 併用禁忌
Atazanavir and Eletriptan: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Atazanavir is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, increasing the risk of vasoconstrictive and other triptan adverse effects. Eletriptan labeling contraindicates use within 72 hours of potent CYP3A4 inhibitors, including HIV protease inhibitors.
この相互作用をわかりやすく説明すると
Atazanavir and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Eletriptan belongs to Central Nervous System.
なぜ起こるのか
Strong inhibition of CYP3A4-mediated first-pass and systemic metabolism of eletriptan.
対処法
Do not give eletriptan within at least 72 hours of atazanavir. Use a triptan not metabolized by CYP3A4, such as rizatriptan or sumatriptan, with attention to its own precautions.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとEletriptanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Eletriptanのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Eletriptan?
MediHelp rates the interaction as contraindicated. Atazanavir and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, increasing the risk of vasoconstrictive and other triptan adverse effects. Eletriptan labeling contraindicates use within 72 hours of potent CYP3A4 inhibitors, including HIV protease inhibitors.
How serious is the interaction between Atazanavir and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give eletriptan within at least 72 hours of atazanavir. Use a triptan not metabolized by CYP3A4, such as rizatriptan or sumatriptan, with attention to its own precautions.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Ceritinib, Clarithromycin. The full list is on the Eletriptan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
