相互作用
Atazanavir + Ergotamine
重症度: 併用禁忌
Atazanavir and Ergotamine: contraindicated interaction.
最終更新日
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概要
Atazanavir inhibits CYP3A4 and can raise ergotamine concentrations. This risks serious ergot toxicity with peripheral vasospasm and ischemia.
この相互作用をわかりやすく説明すると
Atazanavir and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Ergotamine belongs to Central Nervous System.
なぜ起こるのか
CYP3A4 inhibition by atazanavir (usually ritonavir- or cobicistat-boosted) reduces ergotamine clearance.
対処法
Avoid the combination; use a non-ergot alternative for migraine in patients on atazanavir.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとErgotamineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ergotamineのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Ergotamine?
MediHelp rates the interaction as contraindicated. Atazanavir and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir inhibits CYP3A4 and can raise ergotamine concentrations. This risks serious ergot toxicity with peripheral vasospasm and ischemia.
How serious is the interaction between Atazanavir and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-ergot alternative for migraine in patients on atazanavir.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Clarithromycin, Cobicistat. The full list is on the Ergotamine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
