相互作用
Atazanavir + Rabeprazole
重症度: 重大
Atazanavir and Rabeprazole: major interaction.
最終更新日
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概要
Atazanavir needs an acidic environment for absorption. PPIs sharply reduce atazanavir exposure, risking virologic failure and resistance.
この相互作用をわかりやすく説明すると
Atazanavir and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Rabeprazole belongs to Gastrointestinal Tract.
なぜ起こるのか
Increased gastric pH decreases atazanavir solubility and absorption.
対処法
Avoid in treatment-experienced patients. In naive patients on ritonavir-boosted atazanavir, use only a limited PPI dose taken about 12 hours before and monitor viral load.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとRabeprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Rabeprazoleのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Rabeprazole?
MediHelp rates the interaction as major. Atazanavir and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic environment for absorption. PPIs sharply reduce atazanavir exposure, risking virologic failure and resistance.
How serious is the interaction between Atazanavir and Rabeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in treatment-experienced patients. In naive patients on ritonavir-boosted atazanavir, use only a limited PPI dose taken about 12 hours before and monitor viral load.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Dacomitinib. The full list is on the Rabeprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
