相互作用
Atidarsagene autotemcel + Raltegravir
重症度: 重大
Atidarsagene autotemcel and Raltegravir: major interaction.
最終更新日
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概要
Antiretroviral drugs can interfere with the manufacture of this lentiviral gene therapy by inhibiting transduction of mobilized cells. Raltegravir, an integrase inhibitor, may reduce the efficiency of vector integration.
この相互作用をわかりやすく説明すると
Atidarsagene autotemcel and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Raltegravir belongs to Anti Virals.
なぜ起こるのか
Antiretrovirals inhibit lentiviral vector transduction of harvested stem cells during manufacturing.
対処法
Stop raltegravir at least one month before mobilization, or longer to cover drug elimination, and keep it off through apheresis. Arrange alternative HIV management with the treating team.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Atidarsagene autotemcelとRaltegravirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Raltegravirのその他の相互作用
Atidarsagene autotemcelのその他の相互作用
よくある質問
Can I take Atidarsagene autotemcel with Raltegravir?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretroviral drugs can interfere with the manufacture of this lentiviral gene therapy by inhibiting transduction of mobilized cells. Raltegravir, an integrase inhibitor, may reduce the efficiency of vector integration.
How serious is the interaction between Atidarsagene autotemcel and Raltegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop raltegravir at least one month before mobilization, or longer to cover drug elimination, and keep it off through apheresis. Arrange alternative HIV management with the treating team.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
