相互作用
Atidarsagene autotemcel + Efavirenz
重症度: 重大
Atidarsagene autotemcel and Efavirenz: major interaction.
最終更新日
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概要
Antiretrovirals may impair lentiviral transduction of the patient's collected hematopoietic cells and interfere with manufacture of the gene therapy, which could reduce its effectiveness.
この相互作用をわかりやすく説明すると
Atidarsagene autotemcel and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Efavirenz belongs to Anti Virals.
なぜ起こるのか
Reverse transcriptase inhibitors can interfere with lentiviral vector transduction during cell manufacturing.
対処法
Stop efavirenz at least 1 month before cell mobilization, allowing for its long elimination time, and keep it off through apheresis. Arrange alternative HIV management with a specialist.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Atidarsagene autotemcelとEfavirenzの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Efavirenzのその他の相互作用
Atidarsagene autotemcelのその他の相互作用
よくある質問
Can I take Atidarsagene autotemcel with Efavirenz?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals may impair lentiviral transduction of the patient's collected hematopoietic cells and interfere with manufacture of the gene therapy, which could reduce its effectiveness.
How serious is the interaction between Atidarsagene autotemcel and Efavirenz?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop efavirenz at least 1 month before cell mobilization, allowing for its long elimination time, and keep it off through apheresis. Arrange alternative HIV management with a specialist.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
