相互作用
Avanafil + Duvelisib
重症度: 重大
Avanafil and Duvelisib: major interaction.
最終更新日
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概要
Duvelisib inhibits CYP3A4 and may increase avanafil exposure, raising the risk of hypotension, headache, flushing and priapism. Avanafil is a sensitive CYP3A4 substrate, so the effect may be substantial.
この相互作用をわかりやすく説明すると
Avanafil and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avanafil belongs to Genitourinary; Duvelisib belongs to Oncology.
なぜ起こるのか
Duvelisib inhibits CYP3A4, decreasing avanafil metabolism.
対処法
Use the lowest effective avanafil dose, not exceeding labeled limits for CYP3A4 inhibitors, and monitor blood pressure. Consider an alternative if tolerability is poor.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AvanafilとDuvelisibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Avanafilのその他の相互作用
Duvelisibのその他の相互作用
よくある質問
Can I take Avanafil with Duvelisib?
MediHelp rates the interaction as major. Avanafil and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and may increase avanafil exposure, raising the risk of hypotension, headache, flushing and priapism. Avanafil is a sensitive CYP3A4 substrate, so the effect may be substantial.
How serious is the interaction between Avanafil and Duvelisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective avanafil dose, not exceeding labeled limits for CYP3A4 inhibitors, and monitor blood pressure. Consider an alternative if tolerability is poor.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
