相互作用
Avanafil + Isosorbide mononitrate
重症度: 併用禁忌
Avanafil and Isosorbide mononitrate: contraindicated interaction.
最終更新日
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概要
Both avanafil and isosorbide mononitrate relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.
この相互作用をわかりやすく説明すると
Avanafil and Isosorbide mononitrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Isosorbide mononitrate belongs to Cardiovascular.
なぜ起こるのか
PDE5 inhibition potentiates NO/cGMP vasodilation
対処法
Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AvanafilとIsosorbide mononitrateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Avanafilのその他の相互作用
Isosorbide mononitrateのその他の相互作用
よくある質問
Can I take Avanafil with Isosorbide mononitrate?
MediHelp rates the interaction as contraindicated. Avanafil and Isosorbide mononitrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both avanafil and isosorbide mononitrate relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.
How serious is the interaction between Avanafil and Isosorbide mononitrate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
